Amelogenin “nanorods” formation during proteolysis by Mmp-20
نویسندگان
چکیده
منابع مشابه
Amelogenin-cytokeratin 14 interaction in ameloblasts during enamel formation.
The enamel protein amelogenin binds to the GlcNAc-mimicking peptide (GMp) (Ravindranath, R. M. H., Tam, W., Nguyen, P., and Fincham, A. G. (2000) J. Biol. Chem. 275, 39654-39661). The GMp motif is found in the N-terminal region of CK14, a differentiation marker for ameloblasts. The binding affinity of CK14 and amelogenin was confirmed by dosimetric binding of CK14 to recombinant amelogenin (rM1...
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Dentin sialophosphoprotein (DSPP) is a major secretory product of odontoblasts and is critical for proper tooth dentin formation. During dentinogenesis, DSPP is proteolytically cleaved into smaller subunits. These cleavages are proposed activation steps, and failure to make these cleavages is a potential cause of developmental tooth defects. We tested the hypothesis that dentin-resident matrix ...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2011
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2011.07.016